Description

Ziconotide (SNX-111), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide reduces synaptic transmission, and can be used for chronic pain research[1].—Neuroscience-Neuromodulation–C102H172N36O32S7—-[1]Rodrigo B M Silva, et al. Beneficial Effects of the Calcium Channel Blocker CTK 01512-2 in a Mouse Model of Multiple Sclerosis. Mol Neurobiol. 2018 Dec;55(12):9307-9327.|[2]Joseph G McGivern, et al. Ziconotide: a review of its pharmacology and use in the treatment of pain. Neuropsychiatr Dis Treat. 2007 Feb;3(1):69-85.–107452-89-1–2639.13—-O=C(N[C@H](C(N[C@](CSSC[C@H](NC([C@@H](NC(CNC([C@@H](NC1=O)CO)=O)=O)CCCCN)=O)C(N)=O)([H])C(N[C@](CSSC[C@@H](C(N[C@H](C(NCC(N[C@H](C2=O)CCCCN)=O)=O)CCCCN)=O)N)([H])C(N[C@@](C(NCC(N[C@@]3([H])CO)=O)=O)([H])[C@H](O)C)=O)=O)=O)CC(O)=O)[C@](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@](CSSC[C@](C(N[C@@]1([H])CCCNC(N)=N)=O)([H])NC3=O)([H])NC([C@](NC([C@@H](NC(CN2)=O)C)=O)([H])CCCCN)=O)=O)CO)=O)CCCNC(N)=N)=O)CC(C)C)=O)CCSC)=O)([H])CC4=CC=C(O)C=C4–Inflammation/Immunology; Neurological Disease; Cancer–10 mM in DMSO–Calcium Channel–N-type calcium channel–Membrane Transporter/Ion Channel;Neuronal Signaling–Peptides