Description

Ziconotide TFA (SNX-111 TFA), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide TFA reduces synaptic transmission, and can be used for chronic pain research[1].—Neuroscience-Neuromodulation–C116H179F21N36O46S7—-[1]Joseph G McGivern, et al. Ziconotide: a review of its pharmacology and use in the treatment of pain. Neuropsychiatr Dis Treat. 2007 Feb;3(1):69-85.|[2]Rodrigo B M Silva, et al. Beneficial Effects of the Calcium Channel Blocker CTK 01512-2 in a Mouse Model of Multiple Sclerosis. Mol Neurobiol. 2018 Dec;55(12):9307-9327.—-3437.30—-O=C(N[C@H](C(N[C@]1([H])C(N[C@]2([H])C(N[C@@](C(NCC(N[C@@](C(N[C@@](C(N[C@](CCCNC(N)=N)([H])C(N[C@@H](CO)C(NCC(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CSSC1)=O)=O)=O)=O)=O)([H])CSSC[C@@](NC([C@](NC([C@@H](NC(CNC([C@H](CCCCN)NC(CNC([C@H](CCCCN)NC([C@@H](N)CSSC2)=O)=O)=O)=O)=O)C)=O)([H])CCCCN)=O)([H])C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C3=O)=O)=O)=O)=O)=O)([H])CO)=O)=O)([H])[C@H](O)C)=O)=O)=O)CC(O)=O)[C@](N3)([H])CC4=CC=C(O)C=C4.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O–Inflammation/Immunology; Neurological Disease; Cancer–10 mM in DMSO–Calcium Channel–N-type calcium channel–Membrane Transporter/Ion Channel;Neuronal Signaling–Peptides