Sulfo-PDBA-DM4-Get quote

Description
Sulfo-PDBA-DM4 is a agent-linker conjugate composed of a potent a tubulin inhibitor DM4 and a linker Sulfo-PDBA to make antibody agent conjugate (ADC). Sulfo-PDBA is a gluthatione cleavable linker.–Applications-COVID-19-immunoregulation-Formula-C42H60ClN3O15S3-Citation–References-[1]Sun X, et al. Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates. Bioconjug Chem. 2017 May 17;28(5):1371-1381.-CASNumber-1461704-01-7-MolecularWeight-978.58-Compound Purity–SMILES-C[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(CCC(C)(C)SSCCC(C(O)=O)S(=O)(O)=O)=O)=O)=O)C)=C(C(OC)=C4)Cl)C)OC)(NC(O3)=O)O)C)([H])O1-Research_Area-Cancer; Inflammation/Immunology-Solubility-10 mM in DMSO-Target-Drug-Linker Conjugates for ADC-Isoform-Maytansinoids-Pathway-Antibody-drug Conjugate/ADC Related-MCE Product type-ADC Related