Description
PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R (IC50=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo[2].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)–COVID-19-immunoregulation–C59H85N15O11—-[1]D Giuliani, et al. Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br J Pharmacol|[2]P Grieco, et al. Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. J Pept Res–667430-81-1–1180.40–99.86–O=C(N[C@@H](CCCCNC(C[C@@H](C(N1[C@](CCC1)([H])C(N[C@@H](C(N[C@H](C(N2)=O)CCCNC(N)=N)=O)CC3=CC=CC=C3)=O)=O)NC([C@@H](NC(C)=O)CCCC)=O)=O)C(N4[C@@H](CCC4)C(N[C@H](C(N)=O)C(C)C)=O)=O)[C@@H]2CC5=CNC6=CC=CC=C56–Inflammation/Immunology–H2O : 100 mg/mL (ultrasonic)–Melanocortin Receptor–MC4R–GPCR/G Protein;Neuronal Signaling–Peptides
