Description

PD 145065 is a highly potent but non-selective endothelin receptor antagonist with an IC50 value of 4 nM for the ETA receptor for rabbit renal artery vascular smooth muscle cells[1].—–C52H67N7O10—-[1]Warner TD, et al. Reversal of established responses to endothelin-1 in vivo and in vitro by the endothelin receptor antagonists, BQ-123 and PD 145065. Br J Pharmacol. 1994 May;112(1):207-13.–153049-49-1–950.13—-O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)CC1=CNC2=CC=CC=C12)=O)=O)=O)=O)[C@@H](C3C4=CC=CC=C4CCC5=CC=CC=C35)NC(C)=O–Others–10 mM in DMSO–Others—-Others–Peptides