Description

N,O-Didansyl-L-tyrosine cyclohexylammonium is a potent selective thymidylate synthase (TS) inhibitor, acts on TS of Escherichia coli, Lactobacillus casei and human with the IC50 values of 5.0, 3.4 and 119 μM, respectively[1].—Cancer-programmed cell death–C39H46N4O7S2—-[1]T A Fritz, et al. Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase. Chem Biol. 2001 Oct;8(10):981-95.–102783-47-1–746.94—-NC1CCCCC1.O=S(OC(C=C2)=CC=C2C[C@@H](C(O)=O)NS(=O)(C3=CC=CC4=C3C=CC=C4N(C)C)=O)(C5=CC=CC6=C5C=CC=C6N(C)C)=O–Cancer–10 mM in DMSO–Thymidylate Synthase—-Apoptosis–Peptides