Description
Montelukast-d6 is the deuterium labeled Montelukast (sodium). Montelukast sodium is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (Cysltr1). Montelukast sodium can be used for the reseach of asthma and liver injury. Montelukast sodium also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage[1].–Applications–Formula-C35H30D6ClNO3S-Citation–References-[1]Pu S, et, al. Montelukast Prevents Mice Against Acetaminophen-Induced Liver Injury. Front Pharmacol. 2019 Sep 18; 10:1070.;William RHJ, et, al. A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model. Am J Respir Crit Care Med. 2002 Jan 1; 165(1): 108-16.|[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. -CASNumber-1093746-29-2-MolecularWeight-592.22-Compound Purity–SMILES-O=C(O)CC1(CS[C@@H](C2=CC=CC(/C=C/C3=NC4=CC(Cl)=CC=C4C=C3)=C2)CCC5=CC=CC=C5C(C([2H])([2H])[2H])(O)C([2H])([2H])[2H])CC1-Research_Area-Inflammation/Immunology-Solubility-10 mM in DMSO-Target-Isotope-Labeled Compounds;Leukotriene Receptor-Isoform–Pathway-GPCR/G Protein;Others-MCE Product type-Isotope-Labeled Compounds
