Description

Monomethyl auristatin E intermediate-2 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].-4°C (Powder, sealed storage, away from moisture)-Applications–Formula-C15H27NO6-Citation–References-[1]Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.-CASNumber–MolecularWeight-317.38-Compound Purity-97.54-SMILES-OC([C@H](C)[C@@H](OCOC)[C@H]1N(C(OC(C)(C)C)=O)CCC1)=O-Research_Area-cancer-Solubility-10 mM in DMSO-Target-Others-Isoform–Pathway-Others-MCE Product type-ADC Related