Meclofenamic acid-13C6-5mg
Description
Meclofenamic acid-13C6 is the 13C6 labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker.–Applications-COVID-19-immunoregulation-Formula-C8 13C6H11Cl2NO2-Citation–References-[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Conroy MC, et al. Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin J Pain. 1991;7 Suppl 1:S44-8.|[3]Eleftheriou CG, et al. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopicexpression of human rod opsin. Mol Vis. 2017 Jun 16;23:334-345. eCollection 2017.|[4]Huang Y, et al. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res. 2015 Jan;43(1):373-84.-CASNumber–MolecularWeight-302.10-Compound Purity–SMILES-O=C(O)[13C]1=[13CH][13CH]=[13CH][13CH]=[13C]1NC2=C(Cl)C=CC(C)=C2Cl-Research_Area-Inflammation/Immunology-Solubility-10 mM in DMSO-Target-Endogenous Metabolite;Gap Junction Protein;Isotope-Labeled Compounds-Isoform–Pathway-Cytoskeleton;Metabolic Enzyme/Protease;Others-MCE Product type-Isotope-Labeled Compounds