MC-VC(S)-PABQ-Tubulysin M-Get quote

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SKU: HY-128910-Get quote Category: Tags: ,

Description

MC-VC(S)-PABQ-Tubulysin M is a synthetic ADC drug-linker conjugate composed of the tubulin polymerization inhibitor Tubulysin M (an ADC Cytotoxin) (HY-N7053) and MC-VC(S)- PABQ (an ADC linker) is connected. MC-VC(S)-PABQ-Tubulysin M is effective against multidrug-resistant lymphoma cell lines and tumors[1].–Applications-Cancer-programmed cell death-Formula-C66H96N11O13S-Citation–References-[1]Leanna R Staben, et al. Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors. ACS Med Chem Lett. 2017 Sep 5;8(10):1037-1041.-CASNumber-2055896-86-9-MolecularWeight-1283.60-Compound Purity–SMILES-CC(O[C@@H](C1=NC(C(N[C@H](C[C@H](C)C(O)=O)CC2=CC=CC=C2)=O)=CS1)C[C@H](C(C)C)N(C)C([C@@]([C@@H](C)CC)([H])NC([C@@H]3[N+](C)(CCCC3)CC4=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN5C(C=CC5=O)=O)=O)=O)=O)C=C4)=O)=O)=O-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-Drug-Linker Conjugates for ADC;Microtubule/Tubulin-Isoform-Auristatin-Pathway-Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage;Cytoskeleton-MCE Product type-ADC Related

Brand

MEDCHEM EXPRESS

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