Description

LSKL, Inhibitor of Thrombospondin (TSP-1) is a latency-associated protein (LAP)-TGFβ derived tetrapeptide and a competitive TGF-β1 antagonist. LSKL, Inhibitor of Thrombospondin (TSP-1) inhibits the binding of TSP-1 to LAP and alleviates renal interstitial fibrosis and hepatic fibrosis. LSKL, Inhibitor of Thrombospondin (TSP-1) suppresses subarachnoid fibrosis via inhibition of TSP-1-mediated TGF-β1 activity, prevents the development of chronic hydrocephalus and improves long-term neurocognitive defects following subarachnoid hemorrhage (SAH). LSKL, Inhibitor of Thrombospondin (TSP-1) can readily crosse the blood-brain barrier[1][2].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)–Cancer-Kinase/protease–C21H42N6O5—Ann Transl Med. 2021 Dec;9(23):1738.|Antioxidants (Basel). 2023 Nov 21, 12(12), 2024.|Cancers. 2019 Dec 5;11(12):1946.|Cell Tissue Res. 2022 Mar 9.|Environ Pollut. 2020 Apr;259:113915.|Cell Death Dis. 2022 Jul 30;13(7):663.|Front Cell Dev Biol. 18 February 2021.|Front Immunol. 2022 Mar 18;13:853894.|J Am Heart Assoc. 2021 Oct 8;e022701.|J Exp Clin Cancer Res. 2022 Aug 26;41(1):259.-[1]Liao F, et al. LSKL peptide alleviates subarachnoid fibrosis and hydrocephalus by inhibiting TSP1-mediated TGF-β1 signaling activity following subarachnoid hemorrhage in rats. Exp Ther Med. 2016 Oct;12(4):2537-2543. Epub 2016 Aug 31.|[2]Laurent MA, et al. In silico characterization of the interaction between LSKL peptide, a LAP-TGF-beta derived peptide, and ADAMTS1. Comput Biol Chem. 2016 Apr;61:155-61.|[3]Kuroki H, et al. Effect of LSKL peptide on thrombospondin 1-mediated transforming growth factor β signal activation and liver regeneration after hepatectomy in an experimental model. Br J Surg. 2015 Jun;102(7):813-25.–283609-79-0–458.60–99.79–CC(C)C[C@@H](C(N)=O)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC(C)C)N)=O)=O)=O–Cancer–DMSO : 100 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)–TGF-β Receptor—-TGF-beta/Smad–Peptides