Description

Lonodelestat TFA (POL6014 TFA) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat TFA has the potential for the research of cystic fibrosis (CF)[1][2][3].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)—-C73H112F3N15O21—-[1]Lagente V, et al. A novel Protein Epitope Mimetic (PEM) neutrophil elastase (NE) inhibitor, POL6014, inhibits human NE-induced acute lung injury in mice. ATS, San Diego, May 15-20, 2009.|[2]Odile Sellier-Kessler, et al. Inhibition of lung inflammation by a protein epitope mimetic (PEM) neutrophil elastase inhibitor, POL6014, in a sub-chronic tobacco smoke (TS) model in mice. European Respiratory Journal 2013 42: 1762.|[3]Barth P, et al. Single dose escalation studies with inhaled POL6014, a potent novel selective reversible inhibitor of human neutrophil elastase, in healthy volunteers and subjects with cystic fibrosis. J Cyst Fibros. 2020 Mar;19(2):299-304.—-1592.75–99.86–O=C(O)C(F)(F)F.O=C(N(CCC1)[C@]1([H])C(N[C@H](C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@H]2CO)=O)C)=O)([H])[C@H](O)C)=O)CCC(O)=O)=O)CCCCCCCC)=O)[C@](CCC3)([H])N3C([C@@H](NC([C@@H](NC([C@@H](NC([C@@](CCC4)([H])N4C([C@@](CCC5)([H])N5C([C@](NC2=O)([H])[C@@H](C)CC)=O)=O)=O)CCC(N)=O)=O)CCCCN)=O)CC(C=C6)=CC=C6O)=O–Inflammation/Immunology–H2O : 50 mg/mL (ultrasonic)–Elastase—-Metabolic Enzyme/Protease–Peptides