Description

KTX-582 intermediate-3 is an intermediate in the synthesis of KTX-582 (HY-148274) and can be used for ADC preparation. KTX-582 is an IRAK4 degrader and inducer of apoptosis with DC50 of 4 nM and 5 nM for IRAK4 and Ikaros, respectively[1].–Applications-Cancer-programmed cell death-Formula-C26H29F3N4O4-Citation–References-[1]Mainolfi, et al. Preparation of heterocycles as IRAK degraders and uses thereof. World Intellectual Property Organization, WO2020264499 A1. 2020-12-03.-CASNumber-2573304-30-8-MolecularWeight-518.53-Compound Purity–SMILES-CC(O)(C1=C(NC(C2=CC=CC(C(F)(F)F)=N2)=O)C=C3C=NN([C@@H]4CC[C@H](CC4)C(OCC)=O)C3=C1)C-Research_Area-cancer-Solubility-10 mM in DMSO-Target-Others-Isoform–Pathway-Others-MCE Product type-ADC Related