Description
Jingzhaotoxin-III is a potent and selective blocker of Nav1.5 channels, with an IC50 of 348 nM, and shows no effect on other sodium channel isoforms. Jingzhaotoxin-III can selectively inhibit the activation of cardiac sodium channel but not neuronal subtypes, and hopefully represents an important ligand for discriminating cardiac VGSC subtype[1][2].—Neuroscience-Neuromodulation–C174H241N47O46S6—-[1]Xiao Y, et, al. Jingzhaotoxin-III, a novel spider toxin inhibiting activation of voltage-gated sodium channel in rat cardiac myocytes. J Biol Chem. 2004 Jun 18; 279(25): 26220-6.|[2]Rong M, et, al. Molecular basis of the tarantula toxin jingzhaotoxin-III (β-TRTX-Cj1α) interacting with voltage sensors in sodium channel subtype Nav1.5. FASEB J. 2011 Sep; 25(9): 3177-85.–925463-91-8–3919.45—-O=C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(NCC(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@H]2C)=O)=O)=O)=O)NC3=O)C(NCC(NCC(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC9=CNC=CC=CC=C9)C(NCC(N[C@H]CC=CNC=CC=CC=C)=O)=O)=O)=O)=O)=O)NC2=O)C(NCC(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCC)C(N[C@@H](CCC)C(N[C@H]3CSSC[C@@H](C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](CCC)C(O)=O)=O)=O)=O)=O)=O)NC=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N–Neurological Disease–H2O–Sodium Channel—-Membrane Transporter/Ion Channel–Peptides
