Description

IYPTNGYTR, a deamidation-sensitive signature peptide, is a deamidation product of Trastuzumab. IYPTNGYTR can be used to monitor in vivo Trastuzumab metabolism[1].—Metabolism-protein/nucleotide metabolism–C49H73N13O15—-[1]Bults P, et, al. LC-MS/MS-Based Monitoring of In Vivo Protein Biotransformation: Quantitative Determination of Trastuzumab and Its Deamidation Products in Human Plasma. Anal Chem. 2016 Feb 2;88(3):1871-7.–1431957-72-0–1084.18—-O=C(N(CCC1)[C@@H]1C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(N)=O)C(NCC(N[C@H](C(N[C@@H]([C@H](O)C)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)CC(C=C2)=CC=C2O)=O)=O)=O)=O)[C@@H](NC([C@@H](N)[C@@H](C)CC)=O)CC(C=C3)=CC=C3O–Others–H2O–Drug Metabolite—-Metabolic Enzyme/Protease–Peptides