Description
Isofistularin-3 is a direct, DNA-competitive DNMT1 inhibitor, with an IC50 of 13.5 μM. Isofistularin-3, as a DNA demethylating agent, induces cell cycle arrest and sensitization to TRAIL in cancer cells. Isofistularin-3 can be used as an ADC cytotoxin[1].–Applications-Cancer-programmed cell death-Formula-C31H30Br6N4O11-Citation–References-[1]Florean C, et al. Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells. Oncotarget. 2016 Apr 26;7(17):24027-49.-CASNumber–MolecularWeight-1114.01-Compound Purity–SMILES-COC1=C(Br)[C@H](O)[C@@]2(ON=C(C(NC[C@H](O)COC3=C(Br)C=C([C@H](O)CNC(C4=NO[C@]5(C4)C=C(Br)C(OC)=C(Br)[C@H]5O)=O)C=C3Br)=O)C2)C=C1Br-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-ADC Cytotoxin;Apoptosis;Autophagy;DNA Methyltransferase-Isoform-DNMT1;Traditional Cytotoxic Agents-Pathway-Antibody-drug Conjugate/ADC Related;Apoptosis;Autophagy;Epigenetics-MCE Product type-ADC Related
