ALFAGEN, Your Long-Term Partner In Life-Science

Influenza A virus-IN-8-Get quote

Get quote

Add to Wishlist
Add to Wishlist


Influenza A virus-IN-8 (S5) is a macrocyclic peptide with no cytotoxic. Influenza A virus-IN-8 is also a potent Influenza A Virus (IAV) inhibitor (with sufficient protease stability) with IC50s of 6.7 and 6.6 nM for H1 and H5 variants, respectively. Influenza A virus-IN-8 shows good affinitiescan to H1 variants, binds to a conserved region in the HA stem with a Kd of 1.0 nM[1].—COVID-19-anti-virus–C104H142N28O24S—-[1]Pascha MN, et al. Inhibition of H1 and H5 Influenza A Virus Entry by Diverse Macrocyclic Peptides Targeting the Hemagglutinin Stem Region. ACS Chem Biol. 2022 Aug 4.—-2200.48—-O=C(NCC(N)=O)[C@H](CSCC1=O)NC([C@H](C(C)C)NC([C@H](CC2=CNC3=C2C=CC=C3)NC([C@H](CC4=CN=CN4)NC([C@@]([C@@H](C)O)([H])NC([C@H](C)NC([C@H](CC(C)C)NC([C@@]([C@H](O)C)([H])NC(CNC([C@H](CC5=CN=CN5)NC([C@H](CC(O)=O)NC([C@H](CC6=CNC7=C6C=CC=C7)NC([C@H](CCCNC(N)=N)NC([C@H](CC8=CC=CC=C8)NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@@H](N1[H])CC9=CC=C(O)C=C9)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O–Infection–10 mM in DMSO–Influenza Virus—-Anti-infection–Peptides