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HPK1-IN-21-Get quote

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HPK1-IN-21 is a potent inhibitor of HPK1 kinase inhibitor (Ki=0.8 nM). HPK1-IN-21 also has orally active[1].—Cancer-Kinase/protease–C22H25ClFN5O2—-[1]Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1). ACS Med Chem Lett. 2021, 13(1):84-91.–2413804-83-6–445.92—-CN(C(C1=C(C(C2=C(C3=C(NC[C@@]34CC[C@](C(N)=O)(C4)C)N=C2)Cl)=CC=C1N)F)=O)C–Cancer–10 mM in DMSO–MAP4K–MAP4K1/HPK1–MAPK/ERK Pathway–Peptides

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MEDCHEM EXPRESS