Description

hMCH-1R antagonist 1 (Compound 30) is an effective and selective antagonist of human melanin-concentrating hormone receptor 1 (hMCHR1) with an KB value of 3.6 nM. HMCH-1R antagonist 1 can bind to hMCHR1 and hMCHR2 with IC50 values of 65 nM and 49 nM, respectively. HMCH-1R antagonistist 1 can be used for metabolic research[1].—–C49H82N16O11S3—-[1]Bednarek MA, et al. Synthesis and biological evaluation in vitro of selective, high affinity peptide antagonists of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. Biochemistry. 2002 May 21;41(20):6383-90.–353487-64-6–1167.47—-O=C([C@@H](NC([C@@H](NC(CCCCNC([C@@H](NC([C@H](CSSC[C@H](NC(CCCCNC1=O)=O)C(N)=O)NC([C@@H](NC(C)=O)CCCNC(N)=N)=O)=O)CCSC)=O)=O)CCCNC(N)=N)=O)C(C)C)N[C@H]1CC2=CC=C(C=C2)O–Metabolic Disease–10 mM in DMSO–MCHR1 (GPR24)—-GPCR/G Protein;Neuronal Signaling–Peptides