Description

FC131 TFA is a CXCR4 antagonist, inhibits [125I]-SDF-1 binding to CXCR4, with an IC50 of 4.5 nM. Anti-HIV activity[1].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)–COVID-19-anti-virus–C38H48F3N11O8—-[1]Tamamura H, et al. Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131. J Med Chem. 2005 Jan 27;48(2):380-91.–842166-42-1–843.85–98.74–OC(C(F)(F)F)=O.O=C([C@@H](NC([C@@H](NC([C@@H](CC1=CC=C(O)C=C1)NC(CNC2=O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)N[C@H]2CC3=CC4=C(C=CC=C4)C=C3–Infection–DMSO : 100 mg/mL (ultrasonic)–CXCR;HIV–CXCR4;HIV–Anti-infection;GPCR/G Protein;Immunology/Inflammation–Peptides