Description

Exatecan intermediate 11 is an intermediate for the synthesis of Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM)[1].–Applications-Cancer-programmed cell death-Formula-C13H13FN2O3-Citation–References-[1]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82.-CASNumber–MolecularWeight-264.25-Compound Purity–SMILES-CC1=C2C(C(/C(CC2)=NO)=O)=C(NC(C)=O)C=C1F-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-ADC Cytotoxin;Topoisomerase-Isoform-Camptothecins-Pathway-Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage-MCE Product type-ADC Related