Duocarmycin DM (free base)-10 mg

Description
Duocarmycin DM free base, a DNA minor-groove alkylator, is an antibody agent conjugates (ADCs) toxin. Duocarmycin DM free base is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity[1][2].–20°C (Powder, protect from light, stored under nitrogen)-Applications-Cancer-programmed cell death-Formula-C26H26ClN3O3-Citation–References-[1]Patil PC, et al. A Short Review on the Synthetic Strategies of Duocarmycin Analogs that are Powerful DNA Alkylating Agents. Anticancer Agents Med Chem. 2015;15(5):616-630.|[2]Koch MF, et al. Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues. Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13550-4.|[3]Chen KC, et al. Selective cancer therapy by extracellular activation of a highly potent glycosidic duocarmycin analogue. Mol Pharm. 2013;10(5):1773-1782.|[4]Chen KC, Schmuck K, Tietze LF, Roffler SR. Selective cancer therapy by extracellular activation of a highly potent glycosidic duocarmycin analogue. Mol Pharm. 2013;10(5):1773-1782.-CASNumber-1116745-06-2-MolecularWeight-463.96-Compound Purity-98.11-SMILES-O=C(N1C[C@@H](CCl)C2=C1C=C(O)C3=CC=CC=C23)C(N4)=CC5=C4C=CC(OCCN(C)C)=C5-Research_Area-Cancer-Solubility-DMSO : 50 mg/mL (ultrasonic)-Target-ADC Cytotoxin;DNA Alkylator/Crosslinker-Isoform-Daunorubicins/Doxorubicins-Pathway-Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage-MCE Product type-ADC Related