Description

Cycloguanil-d4 (hydrochloride) is the deuterium labeled Cycloguanil hydrochloride. Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1].–Applications–Formula-C11H11D4Cl2N5-Citation–References-[1]Matthaei J, et al. OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil. Clin Pharmacol Ther. 2019 Jan;105(1):190-200.|[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. -CASNumber-1189427-23-3-MolecularWeight-292.20-Compound Purity–SMILES-CC1(N(C2=C([2H])C([2H])=C(C([2H])=C2[2H])Cl)C(N)=NC(N)=N1)C.Cl-Research_Area-Infection-Solubility-10 mM in DMSO-Target-Drug Metabolite;Isotope-Labeled Compounds;Parasite-Isoform-Plasmodium-Pathway-Anti-infection;Metabolic Enzyme/Protease;Others-MCE Product type-Isotope-Labeled Compounds