Description
CTCE-9908 TFA is a potent and selective CXCR4 antagonist. CTCE-9908 TFA induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells[1][2].—Cancer-programmed cell death–C88H148F3N27O25—-[1]Joseph Kwong, et al. An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells. Mol Cancer Ther. 2009 Jul;8(7):1893-905.|[2]Saima Hassan, et al. CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model. Int J Cancer. 2011 Jul 1;129(1):225-32.—-2041.28—-OC1=CC=C(C[C@@H](C(N[C@H](C(N[C@@H](CCCCNC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CCCCN)N)=O)=O)C(C)C)=O)CO)=O)CC(C)C)=O)CO)=O)=O)CCCNC(N)=N)=O)C(N)=O)=O)CCCNC(N)=N)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CCCCN)N)=O)=O)C(C)C)=O)CO)=O)CC(C)C)=O)CO)=O)C=C1.O=C(C(F)(F)F)O–Cancer–H2O–CXCR–CXCR4–GPCR/G Protein;Immunology/Inflammation–Peptides
