Description

Calciseptine, a natural?neurotoxin?isolated from the black mamba Dendroaspis p. polylepis venom. Calciseptine consists of 60 amino acids with four disulfide bonds. Calciseptine specifically blocks L-type?calcium channel[1].—Neuroscience-Neuromodulation–C299H468N90O87S10—-[1]H Schweitz, et al. Calcicludine, a venom peptide of the Kunitz-type protease inhibitor family, is a potent blocker of high-threshold Ca2+ channels with a high affinity for L-type channels in cerebellar granule neurons. Proc Natl Acad Sci U S A. 1994 Feb 1; 91(3): 878–882.–178805-91-9–7036.12—-O=C([C@@H](N)CCCNC(N)=N)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2[C@@H](C)O)=O)CC(N)=O)=O)CCC(O)=O)=O)C(C)C)=O)CSSC[C@H](N3)C(NCC(N[C@H](C(N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N5[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]6CCC(O)=O)=O)[C@@H](C)O)=O)CCC(N)=O)=O)CC7=CC=C(O)C=C7)=O)CCC5)=O)CC8=CNC9=CC=CC=C89)=O)CCSC)=O)C)=O)[C@@H](C)O)=O)CCC4)=O)CSSC[C@H](NC6=O)C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H]CCCNC(N)=N)=O)CC(O)=O)=O)=O)CCCCN)=O)CSSC[C@H](NC=O)C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CC(N)=O)=O)=O)=O)=O)=O)[C@@H](C)O)=O)CCCCN)=O)[C@@H](C)O)=O)C)=O)CCCNC(N)=N)=O)CCC1)=O)CC(C)C)=O)CO)=O)C)=O)CCCCN)=O)CC=CNC=N)=O)[C@H](CC)C)=O)CC=CC=C(O)C=C)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC3=O)=O)CCCNC(N)=N)=O)CCC(O)=O)=O)CO)=O)[C@H](CC)C)=O)CC=CC=C(O)C=C)=O)CCC(O)=O)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)[C@@H](C)O)=O)CCCNC(N)=N)=O)[C@H](CC)C)=O)CC=CC=CC=C)=O)CCSC)=O)CCCCN)=O)CC=CC=C(O)C=C)=O)=O)[C@H](CC)C–Others–10 mM in DMSO–Calcium Channel–L-type calcium channel–Membrane Transporter/Ion Channel;Neuronal Signaling–Peptides