Description

Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site[1][2].—–C19H30N4O10S—-[1]Agniswamy J, et al. Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis. FEBS J. 2007 Sep;274(18):4752-65.|[2]Hayashida M, et al. Cell death induction by CTL: perforin/granzyme B system dominantly acts for cell death induction in human hepatocellular carcinoma cells. Proc Soc Exp Biol Med. 2000 Nov;225(2):143-50.–191338-87-1–506.53—-OC(C[C@@H](C=O)NC([C@H](CCSC)NC([C@H](CO)NC([C@@H](NC(C)=O)CCC(O)=O)=O)=O)=O)=O–Others–10 mM in DMSO–Casein Kinase—-Cell Cycle/DNA Damage;Stem Cell/Wnt–Peptides