Description

1-Cbz-3-Hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-3-Hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.–20°C, 3 years; 4°C, 2 years (Powder)-Applications-Cancer-programmed cell death-Formula-C11H13NO3-Citation–References-[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.-CASNumber-128117-22-6-MolecularWeight-207.23-Compound Purity-99.46-SMILES-O=C(N1CC(O)C1)OCC2=CC=CC=C2-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-ADC Linker;PROTAC Linkers-Isoform-Non-cleavable Linker-Pathway-Antibody-drug Conjugate/ADC Related;PROTAC-MCE Product type-ADC Related