Description

:AbBy Fluor® 405;host:Rabbit;target_protein:PP2A alpha / beta;modification:Unmodified;clonality:Polyclonal;isotype:IgG;concentration:1ug/ul;subcellular_locations:Cytoplasm, Nucleus;source:KLH conjugated synthetic peptide derived from human PP-2A;gene_id:5515;swiss_prot:P67775;applications_with_dilutions:WB(1:300-5000), FCM(1:20-100), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200);cross_reactive_species:Human, Mouse;predicted_cross_reactive_species:Rat, Dog, Cow, Pig, Chicken, Rabbit;background:PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV4 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at ‘Ser-259’.;purification:Purified by Protein A.;storage_buffer:Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.;storage_condition:Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.;:401nm/421nm;synonyms:RP-C; PP2Ac; PP2CA; PP2Calpha; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A-alpha; Replication protein C; PPP2CA