Description

:Biotin;host:Rabbit;target_protein:Cytochrome C;modification:Unmodified;clonality:Polyclonal;isotype:IgG;concentration:1ug/ul;subcellular_locations:Cytoplasm, Cell membrane;source:KLH conjugated synthetic peptide derived from human Cytochrome C;gene_id:54205;swiss_prot:P99999;applications_with_dilutions:WB(), ELISA(1:500-1000), IHC-P(1:200-400), IHC-F(1:100-500);cross_reactive_species:Human, Mouse, Rat, Chicken, Rabbit;predicted_cross_reactive_species:Cow, Pig, Horse, Guinea Pig;background:Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.;purification:Purified by Protein A.;storage_buffer:Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.;storage_condition:Store at -20°C for 12 months.;:N/A;synonyms:CYC; HCS; THC4; Cytochrome c; CYCS