Description

DBCO-acid is a cleavable ADC linker used in the synthesis of ADC linker DBCO-NHS ester (HY-115524 and HY-115545), and agent-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690)[1]. DBCO-acid is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups[1].-4°C (Powder, stored under nitrogen)-Applications-Cancer-programmed cell death-Formula-C19H15NO3-Citation–References-[1]Zimmerman ES, et al. Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system. Bioconjug Chem. 2014 Feb 19;25(2):351-61.-CASNumber-1353016-70-2-MolecularWeight-305.33-Compound Purity-99.63-SMILES-O=C(CCC(O)=O)N(C1)C2=C(C=CC=C2)C#CC3=C1C=CC=C3-Research_Area-Cancer-Solubility-DMSO : 100 mg/mL (ultrasonic)-Target-ADC Linker-Isoform-Cleavable Linker-Pathway-Antibody-drug Conjugate/ADC Related-MCE Product type-ADC Related