Description

(R)-8-Azido-2-(Fmoc-amino)octanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. (R)-8-Azido-2-(Fmoc-amino)octanoic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.–Applications-Cancer-programmed cell death-Formula-C23H26N4O4-Citation–References-[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.-CASNumber-1191429-18-1-MolecularWeight-422.48-Compound Purity–SMILES-OC([C@@H](CCCCCCN=[N+]=[N-])NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)=O-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-ADC Linker-Isoform–Pathway-Antibody-drug Conjugate/ADC Related-MCE Product type-ADC Related