Description

Ald-Ph-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Ald-Ph-PEG4-bis-PEG3-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.–Applications-Cancer-programmed cell death-Formula-C66H94N14O19-Citation–References-[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.-CASNumber–MolecularWeight-1387.53-Compound Purity–SMILES-O=C(CCOCCOCCOCCOCCNC(C1=CC=C(C=O)C=C1)=O)NC(COCCC(NCCOCCOCCOCCNC(CC2=CC=C(C3=NN=C(C)N=N3)C=C2)=O)=O)COCCC(NCCOCCOCCOCCNC(CC4=CC=C(C5=NN=C(C)N=N5)C=C4)=O)=O-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-ADC Linker-Isoform-Cleavable Linker-Pathway-Antibody-drug Conjugate/ADC Related-MCE Product type-ADC Related