Amino-PEG4-bis-PEG3-methyltetrazine-Get quote

Description

Amino-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Amino-PEG4-bis-PEG3-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.–Applications-Cancer-programmed cell death-Formula-C58H90N14O17-Citation–References-[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.-CASNumber–MolecularWeight-1255.42-Compound Purity–SMILES-NCCOCCOCCOCCOCCC(NC(COCCC(NCCOCCOCCOCCNC(CC1=CC=C(C2=NN=C(C)N=N2)C=C1)=O)=O)COCCC(NCCOCCOCCOCCNC(CC3=CC=C(C4=NN=C(C)N=N4)C=C3)=O)=O)=O-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-ADC Linker-Isoform-Cleavable Linker-Pathway-Antibody-drug Conjugate/ADC Related-MCE Product type-ADC Related