Description

Azido-PEG4-C2-acid a PEG-based PROTAC linker can be used in the synthesis of vRucaparib-TP4. Azido-PEG4-C2-acid is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-C2-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.–20°C, 3 years (Powder)-Applications-COVID-19-immunoregulation-Formula-C11H21N3O6-Citation–References-[1]Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019 Dec;15(12):1223-1231.-CASNumber-1257063-35-6-MolecularWeight-291.30-Compound Purity-98.0-SMILES-O=C(O)CCOCCOCCOCCOCCN=[N+]=[N-]-Research_Area-Cancer; Inflammation/Immunology-Solubility-DMSO : 100 mg/mL (ultrasonic)-Target-ADC Linker;PROTAC Linkers-Isoform–Pathway-Antibody-drug Conjugate/ADC Related;PROTAC-MCE Product type-ADC Related