Description

Thalidomide-NH-PEG7 is a synthesized E3 ligase ligand-linker conjugate for ADC. Thalidomide-NH-PEG7 can be connected to the ligand for protein by a linker to form PROTAC iRucaparib-AP6, a highly specific PARP1 degrader[1].–Applications-Cancer-programmed cell death-Formula-C27H39N3O11-Citation–References-[1]Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation.Nat Chem Biol. 2019 Dec;15(12):1223-1231.-CASNumber-2641838-98-2-MolecularWeight-581.61-Compound Purity–SMILES-OCCOCCOCCOCCOCCOCCOCCNC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-Apoptosis;Autophagy;E3 Ligase Ligand-Linker Conjugates-Isoform-Cereblon-Pathway-Apoptosis;Autophagy;PROTAC-MCE Product type-ADC Related