Description

Seco-Duocarmycin TM is a DNA alkylator agent belonging to Duocarmycins family that inhibits DNA synthesis. Seco-Duocarmycin TM is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates (ADC)[1].–Applications-Cancer-programmed cell death-Formula-C25H24N2O6-Citation–References-[1]Gieseg MA, et al. Comparison of the patterns of DNA alkylation by phenol and amino seco-CBI-TMI compounds: use of a PCR method for the facile preparation of single end-labelled double-stranded DNA. Anticancer Drug Des. 1999 Feb;14(1):77-84.-CASNumber-236102-87-7-MolecularWeight-448.47-Compound Purity–SMILES-OC[C@H]1C2=C(C=CC=C3)C3=C(O)C=C2N(C(C4=CC(C=C(OC)C(OC)=C5OC)=C5N4)=O)C1-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-ADC Cytotoxin;DNA Alkylator/Crosslinker-Isoform-Duocarmycins-Pathway-Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage-MCE Product type-ADC Related