Description

MC-Val-Cit-PAB-dimethylDNA31 is a agent-linker conjugate for ADC with potent antitumor activity by using dimethylDNA31, linked via the ADC linker MC-Val-Cit-PAB. DimethylDNA31 has effective bactericidal activity against persisters and stationary-phase S. aureus.–Applications-Cancer-programmed cell death-Formula-C78H101ClN10O19-Citation–References-[1]Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.-CASNumber-1639352-06-9-MolecularWeight-1518.15-Compound Purity–SMILES-O=C(C=CC1=O)N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C2)=CC=C2C[N+](C)(C)C(CC3)CCN3C4=CC(OC(C5=N6)=C(NC(/C(C)=CC=C[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@@H]([C@H](C)[C@@H](OC)/C=C/O7)OC(C)=O)=O)C(C8=C5C9=C(O[C@@]7(C)C9=O)C(C)=C8O)=O)=C6C(O)=C4)=O)=O)=O.[Cl-]-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-Drug-Linker Conjugates for ADC-Isoform-Traditional Cytotoxic Agents-Pathway-Antibody-drug Conjugate/ADC Related-MCE Product type-ADC Related