sulfo-SPDB-DM4-1 mg

Description

sulfo-SPDB-DM4 is a agent-linker conjugate for ADC by using the maytansinebased payload (DM4, an antitubulin agent) via the sulfo-SPDB linker.–80°C, protect from light, stored under nitrogen-Applications-Cancer-programmed cell death-Formula-C46H63ClN4O17S3-Citation–References-[1]Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199.-CASNumber-1626359-59-8-MolecularWeight-1075.66-Compound Purity-99.77-SMILES-C[C@]1([C@@](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)([H])OC([C@H](C)N(C)C(CCC(C)(C)SSCCC(S(=O)(O)=O)C(ON(C4=O)C(CC4)=O)=O)=O)=O)[C@H]([C@@H]([C@](OC5=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N5)O)C)O1-Research_Area-Cancer-Solubility-DMSO : 50 mg/mL (ultrasonic)-Target-Drug-Linker Conjugates for ADC-Isoform-Maytansinoids-Pathway-Antibody-drug Conjugate/ADC Related-MCE Product type-ADC Related