Description

N-myristoyl-RKRTLRRL inhibits binding of PKC substrates. N-myristoyl-RKRTLRRL inhibits Ca2+- and phosphatidylserine (PS)-dependent histone phosphorylation with IC50 of 5 μM.? histone phosphorylation with IC50 of 80 μM[1][2].—–C60H117N21O11—-[1]C A O’Brian, et al. A novel N-myristylated synthetic octapeptide inhibits protein kinase C activity and partially reverses murine fibrosarcoma cell resistance to Adriamycin. Invest New Drugs. 1991 May;9(2):169-79.|[2]David K Crockett, et al. Identification of proteins from formalin-fixed paraffin-embedded cells by LC-MS/MS. Lab Invest. 2005 Nov;85(11):1405-15.–152246-40-7–1308.71—-CC(C)C[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H]([C@H](O)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC(CCCCCCCCCCCCC)=O)=O)=O)=O)=O)=O)=O)=O–cancer–10 mM in DMSO–PKC—-Epigenetics;TGF-beta/Smad–Peptides