Description

Thioether-cyclized helix B peptide, CHBP (TFA) is the TFA form of Thioether-cyclized helix B peptide, CHBP (HY-P5984). Thioether-cyclized helix B peptide, CHBP (TFA) can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2[1].—Cancer-Kinase/protease–C56H93N19O22S.xC2HF3O2—-[1]Cheng Yang, et al. A novel proteolysis-resistant cyclic helix B peptide ameliorates kidney ischemia reperfusion injury. Biochim Biophys Acta. 2014 Nov;1842(11):2306-17.—-1416.52 (free base)—-NC(CC[C@@H]1NC([C@@H](NC([C@@H](NC(CSC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC1=O)CC(C)C)=O)CCC(O)=O)=O)CCCNC(N)=N)=O)C)=O)CC(C)C)=O)CC(N)=O)=O)CO)=O)CO)=O)C(N)=O)=O)CCC(N)=O)=O)CCC(O)=O)=O)=O.O=C(C(F)(F)F)O.[x]–others–10 mM in DMSO–mTOR—-PI3K/Akt/mTOR–Peptides