FA-Phe-Phe-Get quote

Description

FA-Phe-Phe is a furylacryloyl (fa)-amino acid derivative, targeting to Angiotensin-converting Enzyme (ACE). FA-Phe-Phe is also a specific substrate of Cathepsin A[1][2].—Metabolism-protein/nucleotide metabolism–C25H24N2O5—-[1]Mayer M, et al. Mapping the active site of angiotensin-converting enzyme by transferred NOE spectroscopy. J Med Chem. 2000 Jun 1;43(11):2093-9.|[2]Ostrowska H, et al. Lactacystin, a specific inhibitor of the proteasome, inhibits human platelet lysosomal cathepsin A-like enzyme. Biochem Biophys Res Commun. 1997 May 29;234(3):729-32.–83661-95-4–432.47—-OC([C@H](CC1=CC=CC=C1)NC([C@@H](NC(/C=C/C2=CC=CO2)=O)CC3=CC=CC=C3)=O)=O–others–10 mM in DMSO–Angiotensin-converting Enzyme (ACE)—-Metabolic Enzyme/Protease–Peptides