Description

Trichomide A is a potent activator of SHP2. Trichomide A is a natural cyclodepsipeptide. Trichomide A displays immunosuppressive activity against activated T lymphocyte–mediated immune responses in Con A-activated T cells. Trichomide A have the potential for the research of immune-related skin diseases[1].—COVID-19-immunoregulation–C32H55N5O8—-[1]Song Y, et al. Strategies Targeting Protein Tyrosine Phosphatase SHP2 for Cancer Therapy. J Med Chem. 2022;65(4):3066-3079.–1569195-36-3–637.81—-CC[C@@H]([C@H]1C(N(C)[C@@H]([C@H](CC)C)C(N(C)[C@@H](C)C(NCCC(O[C@H](C[C@H](CO)C)C(N2CC[C@H](C)[C@H]2C(N1)=O)=O)=O)=O)=O)=O)C–Inflammation/Immunology–10 mM in DMSO–Phosphatase;SHP2—-Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK–Peptides