Description

p-fin4 is a peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with a Ki of 0.4 μM. p-fin4 restores the memory deficits and displays anxiolytic and antidepressant effects in a scopolamine-treated rat model. p-fin4 is a promising lead compound for novel cognitive enhancers and/or behavioral modulators[1].—Neuroscience-Neuromodulation–C39H53N8O18P—-[1]Szedlacsek HS, et al. Designed Peptide Inhibitors of STEP Phosphatase-GluA2 AMPA Receptor Interaction Enhance the Cognitive Performance in Rats. J Med Chem. 2022;65(1):217-233.–2883747-74-6–952.85—-N[C@@](CCC(O)=O)(C(NCC(N[C@@](Cc1ccc(O)cc1)(C(N[C@@](CC(N)=O)(C(N[C@@](C(C)C)(C(N[C@H](C(N[C@@](CCC(O)=O)(C(O)=O)[H])=O)CC2=CC=C(C=C2)OP(O)(O)=O)=O)[H])=O)[H])=O)[H])=O)=O)[H]–Neurological Disease–10 mM in DMSO–iGluR–AMPA Receptor–Membrane Transporter/Ion Channel;Neuronal Signaling–Peptides