Description

TRV056 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV056 is efficacious in stimulating cellular Gq-mediated signaling. TRV056 can be used to develop the Gq-biased AT1R agonists[1].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)–Neuroscience-Neuromodulation–C52H74N14O13—-[1]Laura M Wingler, et al. Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations. Cell. 2019 Jan 24;176(3):468-478.e11.–812644-79-4–1103.23–99.62–O=C(N(CCC1)[C@@H]1C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)[C@@H](NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H](C(C)C)NC(CNC([C@H](CCCNC(N)=N)NC([C@@H](N)CC(O)=O)=O)=O)=O)=O)CC(C=C3)=CC=C3O)=O)=O)CC4=CN=CN4–Cardiovascular Disease–H2O : 1.96 mg/mL (ultrasonic;adjust pH to 2 with HCl)–Angiotensin Receptor–AT1 Receptor–GPCR/G Protein–Peptides