Description

Homodestcardin, a destruxinbased cyclodepsipeptide, is a immunosuppressant. Homodestcardin, a fungal metabolite, displays pronounced activities against concanavalin A (Con A) activation, with an IC50 value of 0.86 μM[1].—COVID-19-immunoregulation–C32H55N5O7—-[1]Ai Hua Zhang, et al. Discovery of a new class of immunosuppressants from Trichothecium roseum co-inspired by cross-kingdom similarity in innate immunity and pharmacophore motif. Chem Asian J. 2013 Dec;8(12):3101-7.–917382-84-4–621.81—-O=C(N[C@@](C(N([C@@](C(N([C@H]1C)C)=O)([H])[C@@H](C)CC)C)=O)([H])[C@@H](C)CC)[C@@]([C@H]2C)([H])N(CC2)C([C@H](OC(CCNC1=O)=O)CC(C)C)=O–Inflammation/Immunology–10 mM in DMSO–Endogenous Metabolite–Microbial Metabolite–Metabolic Enzyme/Protease–Peptides