Description

Scyllatoxin (Leiurotoxin I) is a peptide toxin, it can be isolated from the venom of the scorpion (Leiurus quinquestriatus hebraeus). Scyllatoxin is a blocker of small-conductance KCa (SK) channel. Scyllatoxin enhances both norepinephrine (NE) and epinephrine (Epi) release in vivo[1].—–C142H237N45O39S7—-[1]Akiyama T, et al. Role of Ca2+-activated K+ channels in catecholamine release from in vivo rat adrenal medulla. Neurochem Int. 2010 Jan;56(2):263-9.|[2]Auguste P, et al. Scyllatoxin, a blocker of Ca(2+)-activated K+ channels: structure-function relationships and brain localization of the binding sites. Biochemistry. 1992 Jan 28;31(3):648-54.–142948-19-4–3423.15—-O=C([C@@H](N)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H]1CCCCN)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)CC(C)C)=O)CO)=O)CCCNC(N)=N)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC3=CNC=N3)=O)CCCCN)=O)C(C)C)=O)=O)CO)=O)CC(C)C)=O)CCC(N)=O)=O)CSSC[C@H](NC4=O)C(N[C@H]2CCC(O)=O)=O)=O)CCSC)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(N)=O)=O)CSC[C@H](NC1=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H]4CCCCN)=O)CC(O)=O)=O)=O)[C@H](CC)C)=O)=O)CC5=CC=CC=C5–Neurological Disease–10 mM in DMSO–Potassium Channel—-Membrane Transporter/Ion Channel–Peptides