Description

Dendrotoxin-I is a potent K+ channels blocker and targets voltage-gated potassium channel subunits KV1.1 and KV1.2. Dendrotoxin-I is a neurotoxin isolated from thevenom of Dendroaspis snakes[1][2][3].—–C312H491N99O83S6—-[1]H Rehm, et al. Purification and subunit structure of a putative K+-channel protein identified by its binding properties for dendrotoxin I. Proc Natl Acad Sci U S A. 1988 Jul;85(13):4919-23.|[2]Tess Wright, et al. Firing frequency and entrainment maintained in primary auditory neurons in the presence of combined BDNF and NT3. Sci Rep. 2016 Jun 23;6:28584.|[3]Hui Zhang, et al. Preparation, characterization, and pharmacodynamics of thermosensitive liposomes containing docetaxel. J Pharm Sci. 2014 Jul;103(7):2177-2183.–107950-33-4–7149.24—-O=C([C@@H](N)CCC(N)=O)N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NC4)=O)CO)=O)CC5=CNC6=CC=CC=C56)=O)[C@@H](C)O)=O)CC7=CC=CC=C7)=O)=O)CCC(O)=O)=O)CSSC[C@H](NC8=O)C(N[C@H](C(N[C@H](C(N[C@H]9[C@@H](C)O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)CCC(N)=O)=O)CCCCN)=O)CCCCN)=O)CCCCN)=O)CCC(N)=O)=O)CC(N)=O)=O)CC=CC=C(O)C=C)=O)CC=CC=C(O)C=C)=O)CC=CC=CC=C)=O)C)=O)CCC3)=O)[C@H](CC)C)=O)CCCCN)=O)CCC(N)=O)=O)CC=CC=C(O)C=C)=O)CSSC[C@H](NC4=O)C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]8CCC(O)=O)=O)CCC(O)=O)=O)[C@H](CC)C)=O)[C@@H](C)O)=O)CCCCN)=O)CC=CC=CC=C)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CO)=O)CC(N)=O)=O)=O)=O)=O)CCCNC(N)=N)=O)=O)CCC2)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CC=CNC=N)=O)CC(C)C)=O)[C@H](CC)C)=O)CSSC[C@H](NC9=O)C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CCCNC(N)=N)=O)[C@H](CC)C)=O)=O)CC(C)C)=O)CCCCN)=O)CCCNC(N)=N)=O)CC(C)C)=O)CCC1–Cancer; Neurological Disease–10 mM in DMSO–Potassium Channel—-Membrane Transporter/Ion Channel–Peptides