Description

Hongotoxin-1, isolated from venom of Centruroides limbatus, is the inhibitor of potassium channel, with IC50 for? Kv1.1, Kv1.2, Kv1.3, and Kv1.6 of 31 pM, 170 pM, 86 pM,and 6000 pM, respectively[1].—Neuroscience-Neuromodulation–C181H299N53O49S7—-[1]Koschak A, et al. Subunit composition of brain voltage-gated potassium channels determined by hongotoxin-1, a novel peptide derived from Centruroides limbatus venom. The Journal of Biological Chemistry. 273 (5): 2639–44.—-4226.13—-O=C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCSC)C(N[C@@H](CC(N)=O)C(NCC(N[C@H]1CCCCN)=O)=O)=O)=O)NC2=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N3[C@@H](CCC3)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H](C(N[C@H]4CCCCN)=O)NC1=O)C(N[C@@H](CC(C)C)C(N5[C@@H](CCC5)C(N6[C@@H](CCC6)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC7=CC=C(C=C7)O)C(N8[C@@H](CCC8)C(N[C@@H](CC9=CNC=N9)C(O)=O)=O)=O)=O)NC4=O)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC=CC=CC=C)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(NCC(N[C@@H](C)C(N[C@H]2CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N–others–10 mM in DMSO–Potassium Channel–Voltage-gated potassium channel–Membrane Transporter/Ion Channel–Peptides