Description

Defensin HNP-3 human is a cytotoxic antibiotic peptide known as “defensin”. Defensin HNP-3 human has inhibitory activity against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. Defensin HNP-3 human is initially synthesized as the 94 amino acids preproHNP(1-94), which is hydrolyzed to proHNP(20-94) and converted to mature HNP(65-94) after the removal of anion precursors[1][2].—COVID-19-immunoregulation–C151H222N44O40S6—-[1]Valore EV, et al. Intramolecular inhibition of human defensin HNP-1 by its propiece. J Clin Invest. 1996 Apr 1;97(7):1624-9. |[2]Ganz T, et al. Defensins. Natural peptide antibiotics of human neutrophils[J]. The Journal of clinical investigation, 1985, 76(4): 1427-1435. –136661-76-2–3486.04—-C(C=1C=2C(NC1)=CC=CC2)[C@@H]3NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@]([C@H](CC)C)(NC(=O)[C@]5(NC(=O)[C@]([C@@H](C)O)(NC(=O)CNC(=O)[C@H](CC6=CC=C(O)C=C6)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@]([C@H](CC)C)(NC(=O)[C@@]7(CSSC[C@](NC(=O)[C@H](CC8=CC=CC=C8)NC(=O)[C@H](C)NC3=O)(C(=O)N[C@H](C(O)=O)CSSC[C@H](NC([C@H](CC(O)=O)N)=O)C(=O)N[C@@H](CC9=CC=C(O)C=C9)C(=O)N[C@](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@]([C@H](CC)C)(C(=O)N[C@](C(=O)N[C@@H](C)C(=O)N7)(CCC)[H])[H])(CSSC5)[H])[H])[H])[H])[H])[H])[H]–Infection–10 mM in DMSO–Antibiotic;Bacterial;Fungal—-Anti-infection–Peptides