Description

SAHM1, a peptide mimetic of a dominant negative form of mastermind-like (MAML), inhibits canonical Notch transcription complex formation. SAHM1 can be used for the research of allergic airway inflammation in mice[1][2].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)–Cancer-programmed cell death–C94H162N36O23S—-[1]Ashley JW, et, al. Notch signaling promotes osteoclast maturation and resorptive activity. J Cell Biochem. 2015 Nov;116(11):2598-609.|[2]KleinJan A, et, al. The Notch pathway inhibitor stapled α-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma. J Allergy Clin Immunol. 2018 Jul;142(1):76-85.e8.–2050906-89-1–2196.58–96.84–C[C@@H](O)[C@@H](C(O)=O)NC([C@H](CO)NC([C@H](CC1=CN=CN1)NC([C@@H](NC([C@]2(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@](C)(CCC/C=C/CCC2)NC([C@H]([C@@H](C)CC)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(O)=O)NC(CCNC(C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)CS)=O)CCCNC(N)=N)=O)C)=O)CC3=CN=CN3)=O)=O)=O–Inflammation/Immunology–10 mM in DMSO–Notch—-Neuronal Signaling;Stem Cell/Wnt–Peptides